A importância dos modelos murinos na caracterização das respostas imunológicas às leishmanioses: uma revisão

Caio Cotta Natale, Paula Melo Seixas, Daniel Manzoni de Almeida


As leishmanioses são doenças causadas por parasitos do gênero Leishmania sp. O grande número dos estudos na construção do conhecimento sobre as formas clínicas das leishmanioses, principalmente na área da Imunologia, contribui para a compreensão dos processos imunológicos envolvidos na reposta às infecções por Leishmania. Propostas de vacinas e tratamentos farmacológicos para essas doenças são, também, realizados em modelos de camundongos (murinos). Aqui, nosso objetivo foi realizar uma revisão ampliada e esquemática sobre os resultados obtidos nos últimos anos sobre as respostas imunes desenvolvidas nos modelos murinos para a leishmaniose. Acreditamos que essa sistematização é importante no direcionamento de estudos e construção de conhecimentos futuros sobre a leishmaniose.


Leishmaniose; Leishmania amazonensis, Leishmania major, Leishmania braziliensis, Leishmania donovani/infantum

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