A IMPORTÂNCIA DA RESSONÂNCIA MAGNÉTICA NO DIAGNÓSTICO DA HEMOCROMATOSE HEREDITÁRIA

Ilana Félix Pinho, Leandro Nobeschi, Rafael Eidi Goto, Bergman Nelson Sanchez Munhoz, Homero José de Farias e Melo

Resumo


A hemocromatose hereditária é uma doença genética relacionada ao acúmulo de ferro no organismo, principalmente no fígado.  A biópsia é o “padrão ouro” para o diagnóstico da concentração de ferro no fígado (LIC), porém é um método invasivo. Por outro lado, os exames sorológicos são sensíveis, mas não específicos.  Estudos relacionados à ressonância magnética (RM) tem sido desenvolvidos pois ela é altamente sensível a presença de ferro, destacando-se as técnicas de relação-sinal- ruído (RSR) e relaxometria. Os métodos de RSR já são aplicáveis atualmente na prática clínica, principalmente o protocolo de Rennes. Já a relaxometria (R2/R2*) gera valores mais precisos do LIC, entretanto exige um investimento de alto custo e não possui protocolos padronizados. A RM é um método não invasivo e com técnicas que possuem potencial para auxiliar e aperfeiçoar o diagnóstico e monitoramento de pacientes com HH.


Palavras-chave


Hemocromatose hereditária; LIC; ressonância magnética; RSR; relaxometria.

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Referências


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Direitos autorais 2016 Ilana Félix Pinho, Leandro Nobeschi, Rafael Eidi Goto, Bergman Nelson Sanchez Munhoz, Homero José de Farias e Melo

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